Abstract: Numerous vaccines are currently available to combat E. coli and salmonella, which provoke the principal enterobacterial diseases in production animals. The use of vaccines requires accurate advance knowledge of the strains responsible for the disease because of the relative lack of cross-protection between sub-types. It is therefore necessary to confirm that the vaccine contains the correct valence: serotype for salmonella and for example, antigens F4 and F5 for E. coli. The method used to vaccinate must be adapted to the characteristics of the infection. There are some restrictions linked, for example, to the zoonotic nature of some of the infections, which limit the use of living vaccines and auto-vaccines. The latter due to legislation designed to prevent the transmission of non-conventional agents.