chapter 1|Introduction
chapter 2|Design and Oversight of Laboratory Animal Facilities
chapter 3|Housing and Care of Laboratory Animals
chapter 4|Animal Needs and Environmental Refinement
chapter 5|Ethical Evaluation of Scientific Procedures: Recommendations for Ethics Committees
chapter 6|Reduction by Careful Design and Statistical Analysis
chapter 7|Animal Models: Selecting and Preparing Animals for a Study
chapter 8|Creation of Genetically Modified Animals
chapter 9|Management of Genetically Modified Rodents
chapter 10|Impact of Handling, Radiotelemetry, and Food Restriction
chapter 11|Basic Procedures: Dosing, Sampling and Immunisation
chapter 12|Imaging Techniques
chapter 13|Anaesthesia and Analgesia
chapter 14|Use of Humane Endpoints to Minimise Suffering
chapter 15|Euthanasia
chapter 16|Education, Training, and Competence
chapter 17|Animal Experimentation and Open Communication