Contents : 1. Scintillation Detectors for Small-Animal Imaging p1/ Tom K. Lewellen and Robert Miyaoka 2. Solid-State Detectors for Small-Animal Imaging p23/ Paolo Russo and Alberto Del Guerra 3. Photon Detectors for Small-Animal Imaging Instrumentation p83/ Dieter Renker and Eckart Lorentz 4. Design Considerations of Small-Animal SPECT Cameras p135/ Steven R. Meikle, Peter L. Kench, and Jianyu Lin 5. Design Considerations for Small Animal PET Scanners p163/ Virginia Ch. Spanoudaki and Craig S. Levin 6. Design Considerations of Small-Animal CT Systems p189/ Erik L. Ritman 7. Small-Animal MRI Instrumentation p211/ Andrew M. Blamire 8. Preclinical Optical Molecular Imaging p241/ Yujie Lu and Ge Wang 9. Advances in Radiotracer Development for Molecular Imaging p275/ Yongjian Liu and Michael J. Welch 10. Image Registration for Multimodality Small-Animal Imaging p319/ Pat Zanzonico 11. Dual-Modality Preclinical SPECT/PET Instrumentation p337/ Alberto Del Guerra and Nicola Belcari 12. Dual-Modality Preclinical SPECT/CT Instrumentation p351/ Youngho Seo 13. Dual-Modality Preclinical PET/CT Instrumentation p367/ Andrew L. Goertzen and Habib Zaidi 14. Dual-Modality Preclinical SPECT/MRI Instrumentation p387/ Douglas J. Wagenaar, Dirk Meier, and Bradley E. Patt 15. Dual-Modality Preclinical PET/MRI Instrumentation p409/ David Schlyer and Bosky Ravindranath 16. Dual-Modality Preclinical PET-OI Concepts and Instrumentation p447/ Jörg Peter 17. Quantifi cation of Small-Animal Imaging Data p467/ Habib Zaidi 18. Animal Handling and Preparation for Imaging p495/ David B. Stout 19. Applications of Small-Animal Imaging in Neurology/ and Psychiatry p517/ Cindy Casteels, Habib Zaidi, and Koen Van Laere 20. Applications of Molecular Small-Animal Imaging in Cardiology p547/ Ravi Marfatia, Sina Tavakoli, and Mehran M. Sadeghi 21. Applications of Molecular Small-Animal Imaging in Oncology p585/ Marybeth A. Pysz and Jürgen K. Willmann 22. Applications of Molecular Small-Animal Imaging in Inflammation and Infection p637/ Alberto Signore, Eri F.J. de Vries, Filippo Galli, and Gaurav Malviya 23. Applications of Small-Animal Molecular Imaging of Gene Expression p685/ June-Key Chung, Hyewon Youn, Joo Hyun Kang, and Keon Wook Kang 24.Applications of Small-Animal Molecular Imaging in Drug Development p715/ Gang Niu and Xiaoyuan Chen 25. Multimodality Molecular Imaging: A Futuristic Outlook p753/ Habib Zaidi and Abass Alavi