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Chordae tendineae rupture in dogs with degenerative mitral valve disease: prevalence, survival, and prognostic factors (114 Cases, 2001-2006).

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Article
H

Serres, François ; Chetboul, Valérie ; Tissier, Renaud ; Clerc, Bernard ; Sampedrano, C. ; Gouni, V. ; Nicolle, Audrey ; Pouchelon, Jean-Louis

Journal of Veterinary Internal Medicine

Unite de Cardiologie d'Alfort, Ecole Nationale Veterinaire d'Alfort, Maisons-Alfort Cedex, France.

2007

Article

Background: Degenerative mitral valve disease (MVD) is the most common heart disease in small breed dogs, and chordae tendineae rupture (CTR) is a potential complication of this disease. The survival time and prognostic factors predictive of survival in dogs with CTR remain unknown. Hypothesis: The prevalence and prognosis of CTR in dogs with MVD increases and decreases, respectively, with heart failure class. Animals: This study used 706 dogs with MVD. Methods: The diagnosis of CTR was based on a flail mitral leaflet with the tip pointing into the left atrium during systole, which was confirmed in several 2-dimension imaging planes using the left and right parasternal 4-chamber views. Results: CTR was diagnosed in 114 of the 706 dogs with MVD (16.1%) and most of these (106/114, 93%) had severe mitral valve regurgitation as assessed by color Doppler mode. CTR prevalence increased with International Small Animal Cardiac Health Council (ISACHC) clinical class (i.e., 1.9, 20.8, 35.5, and 69.6% for ISACHC classes Ia, Ib, II, and III, respectively [P< .05]). Long-term follow-up was available for 57 treated dogs (angiotensin-converting enzyme inhibitors and diuretics) and 58% of these (33/57) survived >1 year after initial CTR diagnosis
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