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Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats.

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Article
H

Adjou, Karim ; Allix, S. ; Ouidja, M.O. ; Backer, S. ; Couquet, C. ; Cornuejols, M.J. ; Deslys, J.P. ; Brugère, Henri ; Brugère-Picoux, Jeanne ; El-Hachimi, H.

JOURNAL OF COMPARATIVE PATHOLOGY

Ecole Nationale Veterinaire d'Alfort (Laboratoire de Pathologie Medicale du Betail and Service de Physiologie et Therapeutique), 7 Avenue du General de Gaulle, 94 704 Maisons-Alfort, Cedex, France.

2007

Article

Immunohistochemical examination demonstrated widespread granular deposits of alpha -synuclein ( alpha SN) in the brains of sheep and goats with natural scrapie, especially in the cornu ammonis and subiculum of the hippocampus; this contrasted with the diffuse and non-granular immunolabelling seen in healthy controls. There was non-regular "co-localization" of PrPSc and alpha SN. The findings resembled those reported in Creutzfeldt-Jakob disease and in experimental prion disease in hamsters and mice. The results suggest that perturbation of alpha SN metabolism plays a role in human and animal prion diseases.
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