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Two Cases of Infertile Bitches With 78,XX/77,X Mosaic Karyotype: A Need for Cytogenetic Evaluation of Dogs With Reproductive Disorders.

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N°spécial
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Switonski, M. ; Szczerbal, I. ; Grewling, J. ; Antosik, P. ; Nizanski, W.N. ; YANG, F.

Journal of heredity

2003

0022-1503

Genetique-130 (R)

Symposium Issue: Advances in Canine and Feline Genomics: Comparative Genome Anat

Url / Doi : http://jhered.oxfordjournals.org/content/by/year

Localisation : Env Alfort (Bibliothèque)

Collection : Génétique Moléculaire

Type de fond : Fonds contemporain

Abstract : A mosaic karyotype 78,XX/77,X was found in two infertile purebred dogs. Cytogenetic investigations were carried out on a large number of metaphase spreads (220 and 473) with the use of conventional Giemsa staining, C-banding, and chromosome painting approaches. The frequencies of the monosomic spreads (77,X) were low: 5.3% and 5.6%. We recommend that at least 90 metaphase spreads be analyzed to allow possible detection of low-level XX/X mosaicism, and we discuss the need for cytogenetic evaluation of dogs with reproductive disorders.

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