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A novel partial t haplotype with a brachyury-independent effect on tail phenotype.

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N°spécial

Fujimoto, A. ; Wakasugi, N. ; Tomita T.

MAMMALIAN GENOME

1995

Genetique-182 (R)

Collection : Génétique Moléculaire

Type de fond : Fonds contemporain

Abstract. The btm (brachyury-interacting tail length modifier) mutation was discovered in strain MOL-NIS derived from Japanese wild mice (Mus musculus molossinus) as an autosomal recessive mutation. Homozygotes for this mutation show a short tail phenotype and, moreover, this mutation causes the tailless character by interacting with the T (brachyury) gene on Chromosome (Chr) 17. Our linkage tests and RFLP analyses suggest that btm is located within the t complex on Chr 17 and represents a new partial t haplotype.

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