Abstract In domestic cats color, shape, hair length, et cetera may differ considerably depending on breed. In addition cats may come from free-roaming parents or from breeders/breeding colonies. Do these differences induce changes in the behavior of cats, especially regarding cat-human interactions? Among the different breeds, some of them are described by breeders as very friendly towards humans, as the Sphynx, a hairless breed, the Maine Coon or the Persian breeds, two of the three main cat breeds in France. We investigated how cat owners describe their interactions with their cats depending on the breed and origin of the cat, and more specifically whether Sphynx cats were friendlier to their owners than other breeds. Questionnaires were distributed to owners for three breeds: Sphynx, Maine Coon and Persian, and the « European » population which included outbred cats, not from breeders. Survey data were analyzed using a multiple correspondence analysis (MCA). There is a clear difference in friendliness between the pure-bred cats compared to « European » cats. Among pure-bred cats, the Sphynx represent a homogeneous group compared to Maine Coons and Persians. In this study, friendliness in cats seems to be a consequence of breeding cats in colony, which ensures early and permanent contact to humans. More data are necessary to assess whether the Sphynx breed has a particular status in its relationships with humans.