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Conversation between apoptosis and autophagy: "Is it your turn or mine?".

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Article

Giansanti, V.. ; Torriglia, A. ; Scovassi, A.I. ; Bakkali-Kassimi L.

APOPTOSIS

1. IGM-CNR, Via Abbiategrasso 207, 27100, Pavia, Italy. 2. Université Pierre et Marie Curie, UMRS 872, Paris, France. 3. Université Paris Descartes, UMRS 872, Paris, France. 4. Ecole Nationale Vétérinaire d'Alfort, CROV, Maisons Alfort, France. 5. INSERM, Centre de Recherches des Cordeliers, UMRS 872, Paris, France.

2011

Article

Volume : 16(4):321-333.

Abstract Drug resistance of cancer cells is often correlated with apoptosis evasion; however, an active involvement of autophagy in this scenario has been recently proposed, based on the evidence that autophagy could exert a protective role toward the activation of apoptosis in cancer cells. In this review, we briefly review the basic features of apoptosis, and we describe in details the molecular patterns of autophagy, with a special emphasis on its still controversial physiological function(s). The crucial factors governing the cross talk between autophagy and apoptosis will be illustrated.
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