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Antigen delivery systems for veterinary vaccine development: Viral-vector based delivery systems.

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Article
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Brun, A. ; Albina, Emmanuel ; Barret, T. ; Chapman, D.A.G. ; Czub, M. ; Dixon, L.K. ; Keil, G.M. ; Klonjkowski, Bernard ; Le Potier, M.F. ; Libeau, G. ; Ortego, J. ; Richardson, Jennifer ; Takamatsu, H.H.

Vaccine

Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain. Centre International de Recherche Agron. pour le Développement (CIRAD), UMR, Contrôle des maladies, F-34398, Montpellier, cedex 05, France. Institute for Animal Health, Pirbright, GU24 ONF, United Kingdom. Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 1N4, Canada. Agence Française de Sécurité Sanitaire des Aliments (AFSSA), BP 53, 22440 Ploufragan, France. Friedrich-Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit, Südufer 10, D-17493 Greifswald-Insel Riems, Germany. UMR 1161 Virologie INRA AFSSA ENVA, F-94704 Maisons-Alfort, France.

2008

Article

Url / Doi : https://doi.org/10.1016/j.vaccine.2008.09.044

Volume : 26(51) ; 6508-6528

The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational design of vaccines effective against viral epizootic diseases. This paper reviews most of the viral-vector based antigen delivery systems (ADSs) recently developed for vaccine testing in veterinary species, including attenuated virus and DNA and RNA viral vectors. Besides their usefulness in vaccinology, these ADSs constitute invaluable tools to researchers for understanding the nature of protective responses in different species, opening the possibility of modulating or potentiating relevant immune mechanisms involved in protection.
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