1. The Human-Animal Bond and Pain 2. Nociception and Pain Mechanisms 3. Pain: Physiologic Consequences and Stress 4. Pain Nomenclature 5. Pain Behaviors and Pain Assessment Scales 6. Quality of Life Assessment 7. Drug Classes and Drugs Used for Pain Therapy: An Overview 8. NSAIDs 9. Opioids 10. Alpha-2s 11. Local Anesthetics 12. Local and Regional Anesthetic Techniques 13. Corticosteroids 14. Other “Drugs” and Injectable Modalities 15. Drug Delivery Methods 16. Preventative” and “Multimodal” Analgesia; “Masking” and Pitfalls: Theory and Consequences 17. Energy Modalities: Therapeutic Laser and Pulsed Electromagnetic Field Therapy 18. Acupuncture 19. Physical Rehabilitation and Exercise 20. Physical Examination with Emphasis on Isolating and Detecting Pain 21. Therapeutic Goals 22. Acute Pain Cases 23. Chronic Pain Cases 24. Cat Specific Considerations 25. Rabbit and Small Mammal Specific Considerations 26. Bird Specific Considerations 27. Reptile Specific Considerations 28. Regulations in Pain and Distress in Laboratory Animals