- Part 1: Commentary on Drug Interactions and their Mechanisms. Pharmacokinetic drug interactions. Pharmacodynamic drug interactions. - Part 2: Drug Interaction Tables. Drug interactions with agents used to treat gastrointestinal disease. Drug interactions with agents used in the treatment of cardiovascular disease. Drug interactions with agents used in respiratory disease. Drug interactions with agents used in the treatment of CNS disorders. Drug interactions with antimicrobial agents. Drug interactions with agents used to treat endocrine disorders. Drug interactions with oral contraceptives. Drug interactions with agents used in immunosuppression and cancer chemotheraphy. Drug interactions with aspirin and other non-steroidal anti-inflammatory agents. Drug interactions with vaccines and interferon. Drug interactions with agents used in anaesthesia. Drug interactions with herbal remedies. Drug interactions with medicinal plastics. Drug interactions with alcohol. Nutrient-drug interactions. Recent and unconfirmed drug interactions. Index. ----- For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship. Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions. The book is conveniently divided into two parts, Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders. If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.