Introduction to the Third Edition Patricia A. Brown and Chester A. Gipson -- 1.Origins of the IACUC Harry Rozmiarek -- 2.Circumstances Requiring an IACUC Marcy Brown and Mary Jo Shepherd -- 3.Creation of an IACUC Marcy Brown and Mary Jo Shepherd -- 4.Reporting Lines of the IACUC Marcy Brown and Mary Jo Shepherd -- 5.General Composition of the IACUC and Specific Roles of the IACUC Members Christian E. Newcomer and William G. Greer -- 6.Frequency and Conduct of Regular IACUC Meetings Sreekant Murthy -- 7.General Format of IACUC Protocol Forms Christian E. Newcomer and William G. Greer -- 8.Submission and Maintenance of IACUC Protocols Kathy Laber and Alison C. Smith -- 9.General Concepts of Protocol Review Ernest D. Prentice, Gwenn S. F. Oki, and Michael D. Mann -- 10.Amending IACUC Protocols Angela M. Mexas and Diane J. Gaertner -- 11.Continuing Review of Protocols Gwenn S.F. Oki and Ernest D. Prentice -- 12.Justification for the Use of Animals Larry Carbone -- 13.Justification of the Number of Animals to Be Used Ed J. Gracely -- 14.Animal Acquisition and Disposition Michael J. Huerkamp, Larry Iten, and David R. Archer -- 15.Animal Housing, Use Sites, and Transportation Robert M. Bigsby and Robin Crisler-Roberts -- 16.Pain and Distress Alicia Z. Karas and Jerald Silverman --17.Euthanasia Peggy J. Danneman -- 18.Surgery Lester L. Rolf, Jr. -- 19.Antigens, Antibodies, and Blood Collection Harold F. Stills, Jr. -- 20.Occupational Health and Safety Robin Lyn Trundy and Susan Stein Cook Personnel Training Howard G. Rush and Melissa C. Dyson -- 22.Confidential and Proprietary Information Marilyn J. Chimes and Priya Sankar -- 23.General Concepts of the Program Review and Facility -- 24.Inspection Joseph D. Thulin and Kenneth P. Allen -- 25.Inspection of Animal Housing Areas Christine A. Boehm and Debra L. Hickman --26.Inspection of Individual Laboratories Neil S. Lipman and Scott E. Perkins Inspection of Surgery Areas Scott E. Perkins and Neil S. Lipman 27.Assessment of Veterinary Care Mark A. Suckow and Bernard J. Doerning -- 28.Laboratory Animal Enrichment Kathryn Bayne and Jennifer N. Camacho -- 29.Animal Mistreatment and Protocol Noncompliance Jerald Silverman -- 30.Postapproval Monitoring Ron E. Banks -- 31.The European Ethical Review Framework: Collaborative Issues Javier Guillen [IACUC = Institutional Animal Care and Use Committee]